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Research Interest
My main research question is how the aneuploid
karyotype affects mitotic chromosome segregation, Publications 
Doubling the deck: tetraploidy induces chromosome shuffling and cancer.
Nicholson J.M. and Cimini D. (2012) Cell Cycle, 18: 3355.
How mitotic errors contribute to karyotypic diversity in cancer.
Nicholson J.M. and Cimini D. (2011) Adv. Canc. Res., 112: 43-75.
Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes.
Klein A., Li N., Nicholson J.M., McCormack A.A., Graessmann A., and Duesberg P. (2010). Cancer Genet. Cytogenet., 200: 79-99.
On the karyotypic origin and evolution of cancer cells.
Nicholson J.M. and Duesberg P. (2009). Cancer Genet. Cytogenet., 194:96-110.
Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.
Li L., McCormack A.A., Nicholson J.M., Fabarius A., Hehlmann R., Sachs R.K., and Duesberg P.H. (2009). Cancer Genet. Cytogenet., 188:1-25. |