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William Silkworth
E-mail: wtsilk1@vt.edu
Telephone:
(540) 231-8933 (Lab)
B.S., SUNY-Potsdam
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Research Interest
My main research interest is the identification of
cellular mechanisms responsible for the formation of kinetochore
mis-attachments in early mitosis. In particular, I am studying how transient
spindle geometry defects lead to the establishment of kinetochore mis-attachments
in both normal and cancer cells.
Images:
Publications
Changes in gene expression and cellular architecture in an ovarian cancer progression model.
Creekmore A.L., Silkworth W.T., Cimini D., Jensen R.V., Roberts P.C., and Schmelz E.M. (2011)
PLoS ONE, 6(3): e17676.
Cytotoxicity of nanostructured vanadium oxide on human cells in vitro.
Rhoads L.S., Silkworth W.T., Roppolo M.L., and Whittingham M.S. (2010).
Toxicol. In Vitro, 24:292-296.
Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy.
Paul R., Wollman R., Silkworth W.T., Nardi I.K., Cimini D., and Mogilner A. (2009).
Proc. Natl. Acad. Sci. U.S.A., 106: 15708-15713.
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells.
Silkworth W.T., Nardi I., Scholl L.M., and Cimini D. (2009).
PloS ONE, 4(8): e6564.
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