Our current research centers on the molecular structure and biochemical functions of signaling transduction systems involved in membrane trafficking and cell signaling. Our goal is to understand how protein domains transduce cell signalling from biological membranes. Our laboratory employs biophysical approaches including high field nuclear magnetic resonance spectroscopy, circular dichroism, computer modeling, fluorescence spectroscopy, and surface plasmon resonance spectroscopy. to determine ligand binding pockets and membrane insertion of protein domains from molecular to atomic resolution. We validate our functional and structural approaches by using normal and disease-associated cell lines. With these tools, we can establish how protein-ligand interactions control the function of proteins by modulating their subcellular localization.

Keywords: Protein domains- lipids – membrane insertion – protein structure – membrane trafficking – subcellular localization of proteins


Wnt Signaling from the Plasma Membrane

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Role of Disabled-2 in Sulfatide-Mediated Platelet Aggregation

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Role of Modular Proteins in Endosomal Protein Trafficking

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Daniel G. S. Capelluto
Associate Professor
Biological Sciences Department
Biocomplexity Institute 263C
1015 Life Science Circle
Blacksburg, VA 24061-0477
Phone: (540) 231-0974

College of Science



Department of Biological Sciences
2125 Derring Hall
Mail Code 0406
Virginia Tech
Blacksburg, VA 24061-0406
Phone: (540) 231-8930
Fax: (540) 231-9307

Last update 31 May 2017