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Publications



All Years
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        2020
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63   Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells.
       Baudoin N.C., Nicholson J.M., Soto K., Martin O., Chen J., Cimini D. (2020).
       eLife 9, e54565

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        2019
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62   Aneuploidy and gene expression: is there dosage compensation?
       Kojima S. and Cimini D. (2019).
       Epigenomics, 11: 1827-1837.

61   Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating
      at the next division.

       He B., Gnawali N., Hinman A.W., Mattingly A.J., Osimani A., Cimini D. (2019).
       Oncotarget, 10: 2660-2674.

60   Exogenous glucocorticoids amplify the costs of infection by reducing resistance and tolerance,
      but effects are mitigated by co-infection.

       Schoenle L.A., Moore I.T., Dudek A.M., Garcia E.B., Mays M., Haussmann M.F., Cimini D., Bonier F. (2019).
       Proceedings of the Royal Society B: Biological Sciences, 286: 20182913.

59   Single-cell analysis reveals that chronic silver nanoparticle exposure induces cell division defects
       in human epithelial cells.

       Garcia E.B., Alms C., Hinman A.W., Kelly C., Smith A., Vance M., Loncarek J., Marr L.C., Cimini D. (2019).
       International Journal of Environmental Research and Public Health, 16: 2061.

58   Environmental stresses induce karyotypic instability in colorectal cancer cells.
       Tan Z., Chan Y.J.A., Chua Y.J.K., Rutledge S.D., Pavelka N., Cimini D., Rancati G. (2019).
       Molecular Biology of the Cell, 30: 42-55.

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        2018
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57   Chromosome segregation: the bigger they come, the harder they fall.
       Baudoin N.C. and Cimini D. (2018).
       Current Biology, 28: R665–R667.

56   A guide to classifying mitotic stages and mitotic defects in fixed cells.
       Baudoin N.C. and Cimini D. (2018).
       Chromosoma, 127: 215-227.

55   Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes
       genomic instability.

       Hyler A.R., Baudoin N.C., Brown M.S., Stremler M.A., Cimini D., Davalos R.V., Schmelz E.M. (2018).
       PLoS ONE, 13: e0194170.

54   Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit
       enhanced invasiveness.

       Wangsa D., Quintanilla I., Torabi K., Vila-Casadesús M., Ercilla A., Klus G., Yuce Z., Galofré C.,
       Cuatrecasas M., Lozano J.J., Agell N., Cimini D., Castells A., Ried T., and Camps J. (2018).
       FASEB Journal, 32: 3502-3517.

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        2017
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53   Transient ALT activation protects human primary cells from chromosome instability induced by
       low chronic oxidative stress.

       Coluzzi E., Buonsante R., Leone S., Asmar A.J., Miller K.L., Cimini D., and Sgura A. (2017).
       Scientific Reports, 7: 43309.

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        2016
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52   Laser microsurgery reveals conserved viscoelastic behavior of the kinetochore.
       Cojoc G., Roscioli E., Zhang L., García-Ulloa A., Shah J.V., Berns M.W., Pavin N., Cimini D., Tolić I.M.,
       and Gregan J. (2016).
       The Journal of Cell Biology , 212: 767-776.
       [Highlighted in commentary by Cabello, Gachet, and Tournier published in the same issue]

51   Selective advantage of trisomic human cells cultured in non-standard conditions.
       Rutledge S.D., Douglas T.A., Nicholson J.M., Vila-Casadesús M., Kantzler C.L., Wangsa D., Barroso-Vilares M.,
       Kale S.D., Logarinho E., and Cimini D. (2016)
       Sci. Rep., 6: 22828.

50   Consequences of aneuploidy in sickness and in health.
       Rutledge S.D. and Cimini D. (2016)
       Curr. Opin. Cell Biol., 40: 41-46.

49   Using photoactivatable GFP to study microtubule dynamics and chromosome segregation.
       He B. and Cimini D. (2016)
       Methods Mol. Biol., 1413: 15-31.

48   Chromosome bridges maintain kinetochore-microtubule attachments throughout mitosis
       and rarely break during anaphase.

       Pampalona J., Roscioli E., Silkworth W.T., Bowden B., Genescà A., Tusell L., and Cimini D. (2016)
       PLoS ONE, 11:e0147420.

47   Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.
       Kajtez J., Solomatina A., Novak M., Polak B., Vukušić K., Rüdiger J., Cojoc G., Milas A., Šumanovac Šestak I.,
       Risteski P., Tavano F., Klemm A.H., Roscioli E., Welburn J., Cimini D., Glunčić M., Pavin N., and Tolić I.M. (2016)
       Nat. Commun., 7:10298.

46   The centrosome: a multifaceted cellular weapon against chromosome instability.
       Guarguaglini G. and Cimini D. (2016)
       Chromosome Res., 24: 1-4.

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        2015
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45   Aurora A kinase contributes to a pole-based error correction pathway.
       Ye A.A., Deretic J., Hoel C.M., Hinman A.W., Cimini D., WelburnJ.P., and MarescaT.J. (2015)
       Curr. Biol., 25: 1842-1851.

44   Characterization of conventional one-step sodium thiosulfate facilitated gold nanoparticle synthesis.
       Saverot S.E., Reese L.M., Cimini D., Vikesland P.J, and Bickford L.R. (2015)
       Nanoscale Res. Lett., 10: 940.

43   Chromosome mis-segregation and cytokinesis failure in trisomic human cells.
       Nicholson J.M., Macedo J.C., Mattingly A.J., Wangsa D., Camps J., Lima V., Gomes A.M., Dória S., Ried T.,
       Logarinho E., and Cimini D. (2015)
       eLife, 4: e05068.

42   Genomic instability: crossing pathways at the origin of structural and numerical chromosome changes.
       Russo A., Pacchierotti F., Cimini D., Ganem N.J., Genescà A., Natarajan A.T., Pavanello S.,
       Valle G., and Degrassi F. (2015)
       Environ. Mol. Mutagenesis, 56: 563-580.

41   Link between aneuploidy and chromosome instability.
       Nicholson J.M. and Cimini D. (2015)
       Internat. Rev. Cell Mol. Biol., 315: 299-317.

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        2014
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40   Modeling chromosome dynamics in mitosis: a historical perspective on models of metaphase
       and anaphase in eukaryotic cells.

       Civelekoglu-Scholey G. and Cimini D. (2014)
       Interface Focus, 4: 20130073.

39   The mitotic origin of chromosomal instability.
       Bakhoum S.F., Silkworth W.T., Nardi I.K., Nicholson J.M., Compton D.A., and Cimini D. (2014)
       Curr. Biol., 24: R148-149.

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        2013
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38   Cancer karyotypes: survival of the fittest.
       Nicholson J.M. and Cimini D. (2013)
       Front. Oncol., 3: 148.

37   Cyclophilin 20-3 Relays a 12-Oxo-Phytodienoic Acid Signal During Stress Responsive Regulation
       of Cellular Redox Homeostasis.

       Park S.W., Li W., Viehhauser A., He B., Kim S., Nilsson A.K., Andersson M.X., Kittle J.D., Ambavaram M.M.R.,
       Luan S., Esker A.R., Tholl D., Cimini D., Ellerstrom M., Coaker G., Mitchell T.K., Pereira A., Dietz K.J.,
       and Lawrence C.B. (2013)
       Proc. Natl. Acad. Sci. U.S.A., 110: 9559-9564.

36   MISP: the missing link between extracellular matrix and astral microtubules.
       Nain A. and Cimini D. (2013)
       Cell Cycle, 12:1821-1822.

35   Dynamic bonds and polar ejection force distribution explain kinetochore oscillations in PtK1 cells.
       Civelekoglu-Scholey G., He B., Shen M., Wan X., Roscioli E., Bowden B., and Cimini D. (2013)
       J. Cell Biol., 201: 577-593.

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        2012
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34   Transient defects of mitotic spindle geometry and chromosome segregation errors.
       Silkworth W.T. and Cimini D. (2012)
       Cell Div., 7: 19.

33   Doubling the deck: tetraploidy induces chromosome shuffling and cancer.
       Nicholson J.M. and Cimini D. (2012)
       Cell Cycle, 18: 3355.

32   The coupling between sister kinetochore directional instability and oscillations in centromere stretch
       in metaphase PtK1 cells.

       Wan X., Cimini D., Cameron L.A., and Salmon E.D. (2012)
       Mol. Biol. Cell, 23: 1035-1046.

31   Timing of centrosome separation is important for accurate chromosome segregation.
       Silkworth W.T., Nardi I.K., Paul R., Mogilner A., and Cimini D. (2012)
       Mol. Biol. Cell, 23: 401-411.

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        2011
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30   How mitotic errors contribute to karyotypic diversity in cancer.
       Nicholson J.M. and Cimini D. (2011)
       Adv. Canc. Res., 112: 43-75.

29   Changes in gene expression and cellular architecture in an ovarian cancer progression model.
       Creekmore A.L., Silkworth W.T., Cimini D., Jensen R.V., Roberts P.C., and Schmelz E.M. (2011)
       PLoS ONE, 6(3): e17676.

28   Merotelic kinetochore attachment: causes and effects.
       Gregan J., Polakova S., Zhang L., M. Tolic-Nørrelykke I., and Cimini D. (2011).
       Trends Cell Biol., 21: 374-381.

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        2009
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27   Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly
       without compromising accuracy.

       Paul R., Wollman R., Silkworth W.T., Nardi I.K., Cimini D., and Mogilner A. (2009).
       Proc. Natl. Acad. Sci. U.S.A., 106: 15708-15713.

26   Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome
       mis-segregation in cancer cells.

       Silkworth W.T., Nardi I., Scholl L.M., and Cimini D. (2009).
       PloS ONE, 4(8): e6564.

25   Telomere and Chromosome Segregation.
       Sgura A. and Cimini D. (2009).
       In “Telomeres: Function, Shortening and Lengthening”. Leonardo Mancini, ed. Nova Science Publishers.

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        2008
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24   Merotelic kinetochore orientation, aneuploidy, and cancer.
       Cimini D. (2008).
       Biochim. Biophys. Acta, 1786: 32-40.

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        2007
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23   Detection and correction of merotelic kinetochore orientation by Aurora B and its partners.
       Cimini D. (2007).
       Cell Cycle, 6: 1558-1564.

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        2006
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22   Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.
       DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. (2006).
       Cell, 127: 969-982.
       [Cited in Faculty of 1000]

21   Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors
       due to merotelic kinetochore orientation.

       Cimini D., Wan X., Hirel C.B., and Salmon E.D. (2006).
       Curr. Biol., 16: 1711-1718.
       [Highlighted in a Dispatch by Zhang and Walczak in Curr. Biol., 16: r677-r678]

20   Kinesin 5-independent poleward flux of kinetochore microtubules in PtK1 cells.
       Cameron L.A., Yang G., Cimini D., Canman J.C., Kisurina-Evgenieva O., Khodjakov A., Danuser G.,
       and Salmon E.D. (2006).
       J. Cell Biol., 173: 173-179, [Cover article]
       [Cited in Faculty of 1000]

19   Chromosomes can congress to the metaphase plate before biorientation.
       Kapoor T.M., Lampson M.A., Hergert P., Cameron L., Cimini D., Salmon E.D., McEwen B.F., and Khodjakov A. (2006).
       Science, 311: 388-391.
       [Cover article; Comment by Rebecca Heald in Science, 311:388-391]
       [Cited in Faculty of 1000]

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        2005
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18   Aneuploidy: a matter of bad connections.
       Cimini D., Degrassi F. (2005).
       Trends Cell Biol., 15: 442-451.

17   Merotelic kinetochores in mammalian tissue cells.
       Salmon E.D., Cimini D., Cameron L.A., and DeLuca J.G. (2005).
       Philos. Trans. R. Soc. Lond. B Biol. Sci., 360: 553-568.

16   The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.
       De Antoni A., Pearson C.G., Cimini D., Canman J.C., Sala V., Nezi L., Mapelli M., Sironi L., Faretta M., Salmon E.D.,
       and Musacchio A. (2005).
       Curr. Biol., 15: 214-225.
       [Cited in Faculty of 1000].

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        2004
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15   Anaphase spindle mechanics prevent mis-segregation of merotelically oriented chromosomes.
       Cimini D., Cameron L.A., and Salmon E.D. (2004).
       Curr. Biol., 14: 2149-2155.
       [Dispatch by Tarun M. Kapoor in Curr. Biol., 14: R1011-R1013; Research Roundup article by William A. Wells
       in J. Cell Biol., 168: 10; Cited in Faculty of 1000]

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        2003
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14   Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells, and error
       correction is achieved by two different mechanisms.

       Cimini D., Moree B., Canman J.C., and Salmon E.D. (2003).
       J. Cell Sci., 116: 4213-4225.
       [Cited in Faculty of 1000]

13   Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome
       segregation defects.

       Cimini D., Mattiuzzo M., Torosantucci L., and Degrassi F. (2003).
       Mol. Biol. Cell., 14: 3821-3833.

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        2002
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12   Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes
       in human primary cells.

       Cimini D., Fioravanti D., Salmon E.D., Degrassi F. (2002).
       J. Cell Sci., 115 (3): 507-515.

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        2001
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11   Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells.
       Cimini D., Howell B.J., Maddox P., Khodjakov A., Degrassi F., and Salmon E.D. (2001).
       Journal of Cell Biology, 153: 517-527.

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        1999
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10   Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells.
       Cimini D., Tanzarella C., and Degrassi F. (1999).
       Mutagenesis, 14: 563-568.

09   A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains
       enriched in retroposon DNA.

       Pittoggi C., Renzi L., Zaccagnini G., Cimini D., Degrassi F., Giordano R., Magnano A.R., Lorenzini R., Lavia P.,
       and Spadafora C. (1999).
       Journal of Cell Science, 112: 3537-3548.

08   Analysis of chromosome loss and non-disjunction in cytokinesis-blocked lymphocytes of 24 male subjects.
       Carere A., Antoccia A., Cimini D., Crebelli R., Degrassi F., Leopardi P., Marcon F., Sgura A., Tanzarella C.,
       and Zijno A. (1999).
       Mutagenesis, 14: 491-496.

07   Development of animal models for adeno-associated virus site-specific integration.
       Rizzuto G., Gorgoni B., Cappelletti M., Lazzaro D., Gloaguen I., Poli V., Sgura A., Cimini D., Ciliberto G., Cortese R.,
       Fattori E., and La Monica N. (1999).
       J. Virology, 73: 2517-2526.

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        1998
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06   Simultaneous inhibition of contractile ring and central spindle formation in mammalian cells treated
       with cytochalasin B.

       Cimini D., Fioravanti D., Tanzarella C., and Degrassi F. (1998).
       Chromosoma, 107: 479-485. [Erratum]

05   Targeted integration of adeno-associated virus-derived plasmids in transfected human cells.
       Pieroni L., Fipaldini C., Monciotti A., Cimini D., Sgura A., Fattori E., Epifano O., Cortese R., Palombo F.,
       and La Monica N. (1998).
       Virology, 249: 249-259.

04   Genetic effects of petroleum fuels. II. Analysis of chromosome loss and hyperploidy in peripheral lymphocytes
       of gasoline station attendants by fluorescence in situ hybridization techniques.

       Carere A., Antoccia A., Cimini D., Crebelli R., Degrassi F., Leopardi P., Marcon F., Sgura A., Tanzarella C.,
       and Zijno A. (1998).
       Environ. Mol. Mutagenesis, 32: 130-138.

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        1997
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03   Topoisomerase II inhibition in mitosis produces numerical and structural chromosomal aberrations
       in human fibroblasts.

       Cimini D., Antoccia A., Tanzarella C., and Degrassi F. (1997).
       Cytogenet. Cell Genet., 76: 61-67.

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        1996
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02   The detection and evaluation of aneugenic chemicals.
       Parry J.M., ......., Cimini D., ......., Hess P. (1996).
       Mutat. Res., 353: 11-46.

01   Effects of 5-azacytidine on the centromeric region of human fibroblasts studied by CREST staining and in situ
       hybridization on cytokinesis-blocked cells.

       Cimini D., Tanzarella C., and Degrassi F. (1996).
       Cytogenet. Cell Genet., 72: 219-224.